Gordon MacGregor

Foundational Sciences Faculty - Physiology Discipline Lead

Campus: IllinoisCOM
Department: Medical Education
Institution: The Chicago School

Biography

I am an old-school electrophysiologist who gets pleasure out of teaching physiology to graduate and medical students. I specialize in renal and gastrointestinal physiology, and their disorders such as electrolyte imbalance, diarrhea, constipation. I also teach basic epithelial physiology and the barrier properties of epithelia. Recently I have been studying the hormonal response of human exposure to high environmental temperature, and measuring regulatory hormones in blood, sweat, saliva and urine.

I have taught or researched at Yale University Medical School, the University of Pittsburgh Medical Center, the University of Alabama in Huntsville and The Alabama College of Osteopathic Medicine.

Education History

Degree	Institution	Year
BSc (Hons) Biochemistry	St. Andrews University , St. Andrews, Scotland	1991
MSc, Molecular Pathology	Dundee University , Dundee, Scotland	1992
PhD, Physiology	Dundee University , Dundee, Scotland	1997
MBA, Management and Entrepreneurship	University of Alabama in Huntsville , Huntsville, AL	2016
LLB, Scots Law	Robert Gordon University , Aberdeen, Scotland	2025

Publications

Chapter
Sadasivan Vidyasagar, Gordon MacGregor (2016). Ussing chamber technique to measure intestinal epithelial permeability. In Andrei I. Ivanov (Ed.) Gastrointestinal Physiology and Diseases (pp. 49-61). New York: Springer.
Journal
Danielle M Glinka and Gordon G MacGregor (2025). The PAR2 Antagonist Larazotide Can Mitigate Acute Histamine-Stimulated Epithelial Barrier Disruption in Keratinocytes: A Potential Adjunct Treatment for Atopic Dermatitis. JID Innov, 5 (4), 100369.
Hasan Alrefai, Shannon L Mathis, Sarah M Hicks, Aleksandra I Pivovarova, Gordon G MacGregor (2020). Salt and water balance after sweat loss: A study of Bikram yoga. Physiol Rep, 8 (22), e14647.
Shannon L Mathis, Aleksandra I Pivovarova, Sarah M Hicks, Hasan Alrefai, Gordon G MacGregor (2020). Calcium loss in sweat does not stimulate PTH release: A study of Bikram hot yoga. Complement Ther Med, 51 , 102417.
Bryce C Simes, Gordon G MacGregor (2019). Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors: A Clinician’s Guide. Diabetes Metab Syndr Obes, 14 (12), 2125—2136.
Aleksandra I Pivovarova, Gordon G MacGregor (2018). Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy. Biomed Pharmacother, 98 , 173-179.
Marissa E Moore, Ashton E Koenig, Megan A Hillgartner, Christopher C Otap, Elizabeth Barnby, Gordon G MacGregor (2017). Abnormal social behavior in mice with tyrosinemia type I is associated with an increase of myelin in the cerebral cortex. Metab Brain Dis, 32 (6), 1829-1841.
Megan A Hillgartner, Sarah B Coker, Ashton E Koenig, Marissa E Moore, Elizabeth Barnby, Gordon G MacGregor (2016). Tyrosinemia type I and not treatment with NTBC causes slower learning and altered behavior in mice. J Inherit Metab Dis, 39 (5), 673-682.
Esad Vucic, Tariq Alfadda, Gordon G MacGregor, Ke Dong, Tong Wang, John P Geibel (2015). Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1. Pflugers Arch, 467 (7), 1457-1468.
Liangjie Yin, Pooja Vijaygopal, Gordon G MacGregor, Rejeesh Menon, Perungavur Ranganathan, Sreekala Prabhakaran, Lurong Zhang, Mei Zhang, Henry J Binder, Paul Okunieff, Sadasivan Vidyasagar (2014). Glucose stimulates calcium-activated chloride secretion in small intestinal cells. Am J Physiol Cell Physiol, 306 (7), C687-96.
Heather M Jones, Mark A Bailey, Catherine J Baty, Gordon G Macgregor, Colin A Syme, Kirk L Hamilton, Daniel C Devor (2007). An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIK1. Channels (Austin), 1 (2), 80-91.
M A Bailey, A Cantone, Q Yan, G G MacGregor, Q Leng, J B O Amorim, T Wang, S C Hebert, G Giebisch, G Malnic (2006). Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet. Kidney Int, 70 (1), 51-9.
Qiang Leng, Gordon G MacGregor, Ke Dong, Gerhard Giebisch, Steven C Hebert (2006). Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism. Proc Natl Acad Sci USA, 103 (6), 1982-7.
Qiang Leng, Kristopher T Kahle, Jesse Rinehart, Gordon G MacGregor, Frederick H Wilson, Cecilia M Canessa, Richard P Lifton, Steven C Hebert (2006). WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). J Physiol, 571 (Pt 2), 275-86.
Anthony D O'Connell, Qiang Leng, Ke Dong, Gordon G MacGregor, Gerhard Giebisch, Steven C Hebert (2005). Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK). Proc Natl Acad Sci USA, 102 (28), 9954-9.
Ke Dong, Lie-Qi Tang, Gordon G MacGregor, Qiang Leng, Steven C Hebert (2005). Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces. EMBO J, 24 (7), 1318-29.
Kristopher T Kahle, Gordon G Macgregor, Frederick H Wilson, Alfred N Van Hoek, Dennis Brown, Thomas Ardito, Michael Kashgarian, Gerhard Giebisch, Steven C Hebert, Emile L Boulpaep, Richard P Lifton (2004). Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc Natl Acad Sci USA, 101 (41), 14877-82.
Kristopher T Kahle, Frederick H Wilson, Qiang Leng, Maria D Lalioti, Anthony D O'Connell, Ke Dong, Alicia K Rapson, Gordon G MacGregor, Gerhard Giebisch, Steven C Hebert, Richard P Lifton (2003). WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet, 35 (4), 372-6.
Ke Dong, LieQi Tang, Gordon G MacGregor, Steven C Hebert (2002). Localization of the ATP/phosphatidylinositol 4,5 diphosphate-binding site to a 39-amino acid region of the carboxyl terminus of the ATP-regulated K+ channel Kir1.1. J Biol Chem, 277 (51), 49366-73..
Carlos G Vanoye, Gordon G MacGregor, Ke Dong, LieQi Tang, Alexandra S Buschmann, Amy E Hall, Ming Lu, Gerhard Giebisch, Steven C Hebert (2002). The carboxyl termini of K(ATP) channels bind nucleotides. J Biol Chem, 277 (26), 23260-70..
Gordon G MacGregor, Ke Dong, Carlos G Vanoye, LieQi Tang, Gerhard Giebisch, Steven C Hebert (2002). Nucleotides and phospholipids compete for binding to the C terminus of KATP channels. Proc Natl Acad Sci USA, 99 (5), 2726-31.

Media Exposure

Appearance
WAAY 31 ABC: UAH Study on ADHD Medication. (May 25, 2018)
WAAY 31 ABC: High School student conducts award-winning research on rare disease. (January 21, 2016)